Which statement is true about progestin-only pills?

Which statement is true about progestin-only pills?

• A. Severe liver disease is a contraindication
• B. They are safe in pregnancy
• C. They are not affected by any medications
• D. They are the same as combined pills

Answer: (A)

Severe liver disease is a contraindication because progestin-only pills rely on the liver to metabolize the hormone, and in significant liver impairment (such as cirrhosis or hepatic tumors) this metabolism can be altered, increasing the risk of adverse effects and liver-related complications. For that reason, this statement is true: progestin-only pills should not be used when there is severe liver disease. In addition, these pills are not safe in pregnancy and their effectiveness can be reduced by certain drug interactions that induce liver enzymes. They also differ from combined pills, since they contain no estrogen.

Severe liver disease is a contraindication because progestin-only pills rely on the liver to metabolize the hormone, and in significant liver impairment (such as cirrhosis or hepatic tumors) this metabolism can be altered, increasing the risk of adverse effects and liver-related complications. For that reason, this statement is true: progestin-only pills should not be used when there is severe liver disease.

In addition, these pills are not safe in pregnancy and their effectiveness can be reduced by certain drug interactions that induce liver enzymes. They also differ from combined pills, since they contain no estrogen.